WATER AND LIFE INTERFACE INSTITUTE
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WALII Publications

2025

Marks, R. A., J T B Ekwealor, M A S Artur, Bondi, L., Boothby, T. C., Carmo, O. M. S., Centeno, D. C., Coe, K. K., Dace, H. J. W., Field, S., Hutt, A., Porembski, S., Thalhammer, A., van, Wood, A. J., Alpert, P., Bartels, D., S Boeynaems, Datar, M. N., Giese, T., & Rhee, S. Y. (2025). Life on the dry side: a roadmap to understanding desiccation tolerance and accelerating translational applications. Nature Communications, 16(1). https://doi.org/10.1038/s41467-025-58656-y 

2024

Alston, J. J., Soranno, A., Holehouse, A. S. (2024) Conserved molecular recognition by an intrinsically disordered region in the absence of sequence conservation. Biophysical Journal. 123(3). https://doi.org/10.1016/j.bpj.2023.11.260

Ginzburg, D. N., 
Cox, J. A., Rhee, S. Y. (2024) Non‐destructive, whole‐plant phenotyping reveals dynamic changes in water use efficiency, photosynthesis, and rhizosphere acidification of sorghum accessions under osmotic stress. Plant Direct. 8(3). https://doi.org/10.1002/pld3.571

Biswas, S., Gollub, E., Yu, F., Ginell, G., Holehouse, A., Sukenik, S., Boothby, T.C. (2024) Helicity of a tardigrade disordered protein contributes to its protective function during desiccation. Protein Science. 33, 2. DOI: https://doi.org/10.1002/pro.4872 

KC, S., Nguyen, K., Nicholson, V., Walgren, A., Trent, T., Gollub, E., Romero, S., Holehouse, A.S., Sukenik, S., Boothby, T.C. (2024) Disordered proteins interact with the chemical environment to tune their protective function during drying. bioRxiv.  DOI: https://doi.org/10.1101/2024.02.28.582506 
 

​Kumara, U.G.V.S.S, Ramirez, J.F., Boothby, T.C. (2024) The effect of sucrose polymer-size on glass transition temperature, glass former fragility, and water retention during drying. Frontiers in Materials. 11. DOI: https://doi.org/10.3389/fmats.2024.1351671
​

Marks, R. A. (2024) Resurrection plants revisited: Bridging the gap between bryophytes and angiosperms to decode desiccation tolerance. New Phytologist. https://doi.org/10.1111/nph.19719 

Marks, R. A., Delgado, P., Makonya, G. M., Cooper, K., VanBuren, R., Farrant, J. M., (2024) Higher order polyploids exhibit enhanced desiccation tolerance in the grass Microchloa caffra, Journal of Experimental Botany. https://doi.org/10.1093/jxb/erae126

Marks, R.A., Van Der Pas, L., Schuster, J. Gilman, I.S., VanBuren, R., (2024) Convergent evolution of desiccation tolerance in grasses. Nat. Plants. 10, 1112–1125. https://doi.org/10.1038/s41477-024-01729-5

Ramirez, J.F., Kumara, U.G.V.S.S, Arulsamy, N., Boothby, T.C. (2024) Water content, transition temperature and fragility influence protection and anhydrobiotic capacity. BBA Advances. DOI: https://doi.org/10.1016/j.bbadva.2024.100115 ​

Sanchez‐Martinez, S., Nguyen, K., Biswas, S., Nicholson, V., Romanyuk, A. V., Ramirez, J., Kc, S., Akter, A., Childs, C., Meese, E. K., Usher, E. T., Ginell, G. M., Yu, F., Gollub, E., Malferrari, M., Francia, F., Venturoli, G., Martin, E. W., Caporaletti, F., Giubertoni, G., Woutersen, S., Sukenik, S., Woolfson, D. N., Holehouse, A. S., Boothby, T. C. (2024) Labile Assembly of a tardigrade protein induces biostasis. Protein Science. 33(4). https://doi.org/10.1002/pro.4941

Shorinola, O., Marks, R., Emmrich, P., Jones, C., Odeny, D., Chapman, M.A., (2024) Integrative and inclusive genomics to promote the use of underutilised crops. Nat Commun. 15, 320. https://doi.org/10.1038/s41467-023-44535-x

VanBuren, R., Nguyen, A., Marks, R.A., Mercado, C., Pardo, A., Pardo, J., Schuster, J., St Aubin, B., Lipham Wilson, M., Rhee, S.Y. (2024) Variability in drought gene expression datasets highlight the need for community standardization. bioRxiv. DOI: 10.1101/2024.02.04.578814 

2023

Field, S., Jang, G.-J., Dean, C., Strader, L. C., Rhee, S. Y. (2023) Plants use molecular mechanisms mediated by biomolecular condensates to integrate environmental cues with development. The Plant Cell. 35(9), 3173–3186. https://doi.org/10.1093/plcell/koad062

Marks, R.A., Amézquita, E.J., Percival, S., Rougon-Cardoso, A., Chibici-Revneanu, C., Tebele, S.M., Farrant, J.M., Chitwood, D.H., VanBuren, R. (2023) A critical analysis of plant science literature reveals ongoing inequities. PNAS. 120, 10. DOI: https://doi.org/10.1073/pnas.2217564120 ​

Packebush, M.H., Sanchez-Martinez, S., Biswas, S., KC, S., Nguyen, K., Ramirez, J.F., Nicholson, V., Boothby, T.C. (2023) Natural and engineered mediators of desiccation tolerance stabilize Human Blood Clotting Factor VIII in a dry state. Scientific Reports. 13, 4542. DOI: https://doi.org/10.1038/s41598-023-31586-9 

Romero-Perez, P. S., Dorone, Y., Flores, E., Sukenik, S., Boeynaems, S. (2023) "When Phased without Water: Biophysics of Cellular Desiccation, from Biomolecules to Condensates. Chemical Reviews.123 (14), 9010-9035, DOI: 10.1021/acs.chemrev.2c00659
​
Sanchez-Martinez, S., Ramirez, J.F., Meese, E.K., Childs, C.A., Boothby, T.C. (2023) The tardigrade protein CAHS D interacts with, but does not retain, water in hydrated and desiccated systems. Scientific Reports. 13, 10449. DOI: 10.1038/s41598-023-37485-3 

2022

Chen, A., Tapia, H., Goddard, J. M., & Gibney, P. A. (2022) Trehalose and its applications in the food industry. Comprehensive Reviews in Food Science and Food Safety, 1–34. DOI: 10.1111/1541-4337.13048
​​

Nguyen, K., KC, S., Gonzalez, T.,
Tapia, H., Boothby, T. C. (2022) Trehalose and tardigrade CAHS proteins work synergistically to promote desiccation tolerance. Commun. Biol 5, 1046. DOI: 10.1038/s42003-022-04015-2

2021

Boothby, T. C. (2021) Water content influences the vitrified properties of CAHS proteins. Mol. Cell 81, 411–413. PMID: 33545054

Dorone, Y., Boeynaems, S., Flores, E., Jin, B., Hateley, S., Bossi, F., Lazarus, E., Pennington, J. G., Michiels, E., De Decker, M., Vints, K., Baatsen, P., Bassel, G. W., Otegui, M. S., Holehouse, A. S., Exposito-Alonso, M., Sukenik, S., Gitler, A. D., Rhee, S. Y. (2021) A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation. Cell 184. PMID: 34233164

Hesgrove, C. S., Nguyen, K. H., Biswas, S., Childs, C. A., Shraddha, K. C., Medina, B. X., Alvarado, V.,
Sukenik, S., Yu, F., Malferrari, M., Francia, F., Venturoli, G., Martin, E. W., Holehouse, A. S., Boothby, T. C. (2021) Tardigrade CAHS Proteins Act as Molecular Swiss Army Knives to Mediate Desiccation Tolerance Through Multiple Mechanisms. bioRxiv.  DOI: 10.1101/2021.08.16.456555

Marks, R. A., Farrant, J. M., Nicholas McLetchie, D., VanBuren, R. (2021) Unexplored dimensions of variability in vegetative desiccation tolerance. Am. J. Bot. 108, 346–358. PMID: 33421106

Moses, D., Guadalupe, K., Yu, F., Flores, E., Perez, A., McAnelly, R., Shamoon, N. M., Cuevas-Zepeda, E., Merg, A., Martin, E. W.,
Holehouse, A. S., Sukenik, S. (2021) Hidden structure in disordered proteins is adaptive to intracellular changes. bioRxiv. DOI: 10.1101/2021.11.24.469609

2020

Moses, D., Yu, F., Ginell, G. M., Shamoon, N. M., Koenig, P. S., Holehouse, A. S., Sukenik, S. (2020) Revealing the Hidden Sensitivity of Intrinsically Disordered Proteins to their Chemical Environment. J. Phys. Chem. Lett. 11, 10131–10136. PMID: 33191750

Pardo, J., Man Wai, C., Chay, H., Madden, C. F., Hilhorst, H. W. M., Farrant, J. M.,
VanBuren, R. (2020) Intertwined signatures of desiccation and drought tolerance in grasses. Proc. Natl. Acad. Sci. U. S. A. 117, 10079–10088. PMID: 32327609

2017-2019

Boothby, T. C., Tapia, H., Brozena, A. H., Piszkiewicz, S., Smith, A. E., Giovannini, I., Rebecchi, L., Pielak, G. J., Koshland, D., Goldstein, B. (2017) Tardigrades Use Intrinsically Disordered Proteins to Survive Desiccation. Mol. Cell 65, 975–984.e5. PMID: 28306513
​
Exposito-Alonso, M., Vasseur, F., Ding, W., Wang, G., Burbano, H. A., Weigel, D. (2018) Genomic basis and evolutionary potential for extreme drought adaptation in Arabidopsis thaliana. Nat Ecol Evol 2, 352–358. PMID: 29255303

Fleming, M. B., Richards, C. M., Walters, C. (2017) Decline in RNA integrity of dry-stored soybean seeds correlates with loss of germination potential. J. Exp. Bot. 68, 2219–2230. PMID: 28407071

Koshland D. and Tapia, H. (2019) Desiccation tolerance: an unusual window into stress biology. MBoC 30, 737–741. PMID: 30870092
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MICHIGAN STATE UNIVERSITY LAND ACKNOWLEDGEMENT
“WALII operates in part out of
Michigan State University. We acknowledge that Michigan State University occupies the ancestral, traditional, and contemporary Lands of the Anishinaabeg – the Three Fires Confederacy of Ojibwe, Odawa, and Potawatomi peoples. We affirm Indigenous sovereignty and hold Michigan State University accountable to the needs of American Indian and Indigenous peoples.”
National Science Foundation logo.
WALII is funded by NSF DBI grant #2213983
  • Home
  • About
    • Mission, Vision, Values
    • Institute Themes & Structure
    • Team
    • Code of Conduct
    • Scientific Advisory Board
    • Researcher Spotlight
    • Contact Us
  • Research
    • Overview
    • Surviving the Solid State
    • Rehydration & Recovery
    • Molecular Engineering
    • Evolutionary Dynamics
    • Integration of Themes
  • Training
    • Overview
    • Summer Internship Program
  • Careers
  • Events
  • Outreach
    • Overview
    • Seed Germination Necklace
    • Seed Longevity Experiments
    • Tardigrade Hunting
  • Publications
  • Resources
    • Training